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Molecules 2015, 20(7), 13041-13054; doi:10.3390/molecules200713041

Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver

1
Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Yangchon-ku, Seoul 158-710, Korea
2
Life Science Research Institute, Novarex Co., Ltd, Ochang, Cheongwon, Chungbuk 363-885, Korea
3
College of Pharmacy, Pusan National University, Pusan 609-735, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 14 May 2015 / Revised: 8 July 2015 / Accepted: 10 July 2015 / Published: 20 July 2015
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [1390 KB, uploaded 20 July 2015]   |  

Abstract

This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and interleukin (IL)-6 in BV2 (mouse brain microglia) cells. Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in the livers of t-BHP-treated mice models. This result suggested that mechanistic-based evidence substantiating the traditional claims of licorice extract and its three bioactive components can be applied for the treatment of inflammation-related disorders, such as oxidative liver damage and inflammation diseases. View Full-Text
Keywords: licorice extract; oxidative liver damage; anti-inflammation; glycyrrhizic acid; liquiritin; hepatoprotective effect licorice extract; oxidative liver damage; anti-inflammation; glycyrrhizic acid; liquiritin; hepatoprotective effect
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yu, J.-Y.; Ha, J.Y.; Kim, K.-M.; Jung, Y.-S.; Jung, J.-C.; Oh, S. Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver. Molecules 2015, 20, 13041-13054.

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