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Molecules 2015, 20(7), 12732-12756; doi:10.3390/molecules200712732

Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents

1
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
2
Division of Biochemistry, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, SE-171 77 Stockholm, Sweden
*
Authors to whom correspondence should be addressed.
Academic Editor: Tzi Bun NG
Received: 1 April 2015 / Revised: 18 June 2015 / Accepted: 8 July 2015 / Published: 14 July 2015
(This article belongs to the Special Issue Thioredoxin and Glutathione Systems)
View Full-Text   |   Download PDF [1952 KB, uploaded 14 July 2015]   |  

Abstract

The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine nucleotide disulfide oxidoreductases playing a central role in cellular redox homeostasis and signaling pathways. Recently, these selenoproteins have emerged as promising therapeutic targets for anticancer drug development, often being overexpressed in tumor cells and contributing to drug resistance. Herein, we summarize the current knowledge on metal- and semimetal-containing molecules capable of hampering mammalian TrxRs, with an emphasis on compounds reported in the last decade. View Full-Text
Keywords: thioredoxin reductase; enzyme inhibitors; metal- and semimetal-based compounds; anticancer agents thioredoxin reductase; enzyme inhibitors; metal- and semimetal-based compounds; anticancer agents
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gandin, V.; Fernandes, A.P. Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents. Molecules 2015, 20, 12732-12756.

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