Next Article in Journal
Synthesis of Oxygen Heterocycles via Aromatic C-O Bond Formation Using Arynes
Next Article in Special Issue
A New Furofuran Lignan Diglycoside and Other Secondary Metabolites from the Antidepressant Extract of Castilleja tenuiflora Benth
Previous Article in Journal
Microbiological Assessment, Nutritional Characterization and Phenolic Compounds of Bee Pollen from Mellipona mandacaia Smith, 1983
Previous Article in Special Issue
Riluzole as a Neuroprotective Drug for Spinal Cord Injury: From Bench to Bedside
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(7), 12545-12557; doi:10.3390/molecules200712545

Acerogenin A from Acer nikoense Maxim Prevents Oxidative Stress-Induced Neuronal Cell Death through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse Hippocampal HT22 Cell Line

1
Department of Biomedical Chemistry, College of Health and Biomedical Science, Konkuk University, Chung-Ju 380-701, Korea
2
Research Institute for Biological Functions, Chubu University, 1200 Matsumoto, Kasugai, Aichi 487-8501, Japan
3
College of Pharmacy, Wonkwang University, Iksan 570-749, Korea
4
Department of Biochemistry, Inha University School of Medicine, Incheon 400-712, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Koulen
Received: 27 May 2015 / Revised: 2 July 2015 / Accepted: 7 July 2015 / Published: 9 July 2015
View Full-Text   |   Download PDF [1329 KB, uploaded 9 July 2015]   |  

Abstract

Oxidative cell damage contributes to neuronal degeneration in many central nervous system (CNS) diseases such as Parkinson’s disease, Alzheimer’s disease, and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a key role in the pathogenesis of neuronal diseases. The stem bark of Acer nikoense Maxim (Aceraceae) is indigenous to Japan; it has been used in folk medicine as a treatment of hepatic disorders and eye diseases. Acerogenin A, a natural compound isolated from Japanese folk medicine A. nikoense, showed neuroprotective effects and reactive oxygen species (ROS) reduction on glutamate-induced neurotoxicity by inducing the expression of HO-1 in mouse hippocampal HT22 cells. Furthermore, acerogenin A caused the nuclear accumulation of nuclear factor-E2-related factor 2 (Nrf2) and the activation of the PI3K/AKT signaling pathways. In this study, we demonstrated that acerogenin A effectively prevents glutamate-induced oxidative damage, and HO-1 induction via PI3K/Akt and Nrf2 pathways appears to play a key role in the protection of HT22 cells. Therefore, this study implies that the Nrf2/HO-1 pathway represents a biological target and that acerogenin A might be a candidate for the prevention of neurodegeneration. View Full-Text
Keywords: acerogenin A; mouse hippocampal HT22 cells; neuro-protective effects; heme oxygenase-1; nuclear factor-E2-related factor 2 acerogenin A; mouse hippocampal HT22 cells; neuro-protective effects; heme oxygenase-1; nuclear factor-E2-related factor 2
Figures

Figure 1a

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lee, D.-S.; Cha, B.-Y.; Woo, J.-T.; Kim, Y.-C.; Jang, J.-H. Acerogenin A from Acer nikoense Maxim Prevents Oxidative Stress-Induced Neuronal Cell Death through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse Hippocampal HT22 Cell Line. Molecules 2015, 20, 12545-12557.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top