Next Article in Journal
Quantification of Polyfunctional Thiols in Wine by HS-SPME-GC-MS Following Extractive Alkylation
Previous Article in Journal
Protective Effect of Procyanidin B2 against CCl4-Induced Acute Liver Injury in Mice
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(7), 12266-12279; doi:10.3390/molecules200712266

Synthesis and Evaluation of New Podophyllotoxin Derivatives with in Vitro Anticancer Activity

1
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
2
Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin 300162, China
3
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 28 April 2015 / Revised: 28 June 2015 / Accepted: 29 June 2015 / Published: 6 July 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [782 KB, uploaded 6 July 2015]   |  

Abstract

A series of novel podophyllotoxin derivatives were designed and synthesized. The cytotoxic activities of these compounds were tested against three tumor cell lines (HeLa, K562, and K562/A02). Most of the derivatives (IC50 = 1–20 μM) were found to have stronger cell growth inhibitory activity than positive control etoposide. Among them, 4β-N-[(E)-(5-((4-(4-nitrophenyl)-piperazin-1-yl)methyl)furan-2-yl)prop-2-en-1-amine]-4-desoxy-podophyllotoxin (9l) demonstrated significant inhibitory activity against HeLa, K562, and K562/A02 cell lines with IC50 values of 7.93, 6.42, 6.89 μM, respectively. View Full-Text
Keywords: podophyllotoxin; MDR; synthesized; antitumor activity podophyllotoxin; MDR; synthesized; antitumor activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cheng, W.-H.; Shang, H.; Niu, C.; Zhang, Z.-H.; Zhang, L.-M.; Chen, H.; Zou, Z.-M. Synthesis and Evaluation of New Podophyllotoxin Derivatives with in Vitro Anticancer Activity. Molecules 2015, 20, 12266-12279.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top