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Molecules 2015, 20(7), 12114-12124; doi:10.3390/molecules200712114

Quantitative 1H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China
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Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 5 June 2015 / Revised: 21 June 2015 / Accepted: 25 June 2015 / Published: 2 July 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [992 KB, uploaded 3 July 2015]   |  

Abstract

A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d6 using 2,4-dinitrotoluene as the internal standard. In this study, the method’s linearity, range, limit of quantification, stability, precision, and accuracy were validated. The results were consistent with those obtained from high-performance liquid chromatography analysis. Thus, the proposed method is a useful and practical tool for the determination of tadalafil in bulk drugs and its tablets. View Full-Text
Keywords: tadalafil; quantitative analysis; quantitative proton nuclear magnetic resonance; 2,4-dinitrotoluene tadalafil; quantitative analysis; quantitative proton nuclear magnetic resonance; 2,4-dinitrotoluene
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yang, Q.; Qiu, H.; Guo, W.; Wang, D.; Zhou, X.; Xue, D.; Zhang, J.; Wu, S.; Wang, Y. Quantitative 1H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets. Molecules 2015, 20, 12114-12124.

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