Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model
Abstract
:1. Introduction
2. Results and Discussion
2.1. Results
2.1.1. Effect of DHCA on Brain Infarct Volume and Sensory-Motor Function Deficit
2.1.2. Effect of DHCA on BWC and EB Extravasation
2.1.3. Effect of DHCA on MMP-2 and MMP-9 Protein Expression
2.1.4. Effect of DHCA on MMP-2 and MMP-9 Activity
2.2. Discussion
3. Experimental Section
3.1. DHCA Preparation
3.2. Animals
3.3. Focal Cerebral Ischemia Rat Model Induction and Treatment
3.4. Balance Beam Test
3.5. Measurement of Infarct Volume
3.6. Measurement of BWC
3.7. Measurement of EB Extravasation
3.8. Western Blot
3.9. In Vitro Zymography
3.10. Statistical Analysis
4. Conclusion
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Lee, K.; Lee, B.-J.; Bu, Y. Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model. Molecules 2015, 20, 11930-11940. https://doi.org/10.3390/molecules200711930
Lee K, Lee B-J, Bu Y. Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model. Molecules. 2015; 20(7):11930-11940. https://doi.org/10.3390/molecules200711930
Chicago/Turabian StyleLee, Kyungjin, Beom-Joon Lee, and Youngmin Bu. 2015. "Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model" Molecules 20, no. 7: 11930-11940. https://doi.org/10.3390/molecules200711930