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Molecules 2015, 20(7), 11915-11929; doi:10.3390/molecules200711915

Urinary Metabolomic Profiling Reveals the Effect of Shenfu Decoction on Chronic Heart Failure in Rats

1,†
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2,†
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1
,
3
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3
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4,5,* and 3,*
1
Zhong Yuan Academy of Biological Medicine, Liaocheng People's Hospital/Affiliated Liaocheng Hospital, Taishan Medical University, 67 Dong Chang Xi Lu, Liaocheng 252000, China
2
Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China
3
Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China
4
Biomedical Engineering School, Carlos III University, Avda Universidad 30, Leganes, Madrid 28911, Spain
5
Metabolomics, Genome Center, UC Davis, 451 Health Sciences Drive, Davis, CA 95616, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 8 June 2015 / Revised: 18 June 2015 / Accepted: 22 June 2015 / Published: 30 June 2015
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [3676 KB, uploaded 30 June 2015]   |  

Abstract

Shenfu decoction (SFD) can be used to treat patients with sign of Yangqi decline or Yang exhaustion related to chronic heart failure (CHF). We conducted a gas chromatography with time-of-flight mass spectrometer (GC/TOF–MS)-based metabolomic study to increase the understanding of CHF and assess the efficacies and mechanisms of SFD in treating CHF induced by coronary artery ligation in rats. Based on unsupervised principal component analysis, there was a clear separation between the CHF and sham surgery group, which revealed that CHF disturbed the metabolism of endogenous substances and significantly altered the urine metabolite fingerprints. After SFD treatment, the metabolomics profile found in CHF was significantly reversed, shifting much closer to normal controls and sham surgery group, indicating that SFD has therapeutic effects in CHF, which is in accordance with the hemodynamic assay results. Metabolomic pathway analysis demonstrated that several pathways including fatty acid biosynthesis, fatty acid elongation, steroid biosynthesis, galactose metabolism, and amino acid metabolism were significantly altered in CHF rats. Therefore, we may infer that SFD shows therapeutic efficacy in CHF by restoring these disturbed metabolic pathways, especially those related to energy metabolism. This study offers new methodologies for increasing the understanding of CHF and systematically characterizing the efficacies and mechanisms of SFD in treating CHF. View Full-Text
Keywords: chronic heart failure; Shenfu decoction; metabolomics; GC/TOF–MS; metabolomic pathway analysis chronic heart failure; Shenfu decoction; metabolomics; GC/TOF–MS; metabolomic pathway analysis
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MDPI and ACS Style

Yang, D.; Wang, X.; Wu, Y.; Lu, B.; Yuan, A.; Leon, C.; Guo, N. Urinary Metabolomic Profiling Reveals the Effect of Shenfu Decoction on Chronic Heart Failure in Rats. Molecules 2015, 20, 11915-11929.

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