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Molecules 2015, 20(7), 11765-11776; doi:10.3390/molecules200711765

A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum

1
Department of Life Sciences, University of Modena and Reggio Emilia, viale Caduti in Guerra 127, 41121 Modena, Italy
2
Department of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 8 May 2015 / Revised: 22 June 2015 / Accepted: 24 June 2015 / Published: 26 June 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1271 KB, uploaded 1 July 2015]   |  

Abstract

Multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. The antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Nannizzia cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Arthroderma gypseum, Trichophyton rubrum and Trichophyton tonsurans. α-Bisabolol showed the best antifungal activity against all fungi and in particular; against M. gypseum. Further investigations were conducted on this fungus to evaluate the inhibition of spore germination and morphological changes induced by α-bisabolol by TEM. View Full-Text
Keywords: antifungal activity; dermatophytes; M. gypseum; α-bisabolol; TEM; skin lightener antifungal activity; dermatophytes; M. gypseum; α-bisabolol; TEM; skin lightener
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Romagnoli, C.; Baldisserotto, A.; Malisardi, G.; Vicentini, C.B.; Mares, D.; Andreotti, E.; Vertuani, S.; Manfredini, S. A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum. Molecules 2015, 20, 11765-11776.

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