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Molecules 2015, 20(6), 9560-9574; doi:10.3390/molecules20069560

Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds

1
Faculty of Medicine, Pharmacy and Dental Medicine, Vasile Goldiș Western University of Arad, 86, Rebreanu Street, Arad 310414, Romania
2
SC PlantExtrakt SRL, Rădaia 407059, Cluj, Romania
3
Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 8, V. Babes Street, Cluj-Napoca 400010, Romania
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 20 April 2015 / Revised: 17 May 2015 / Accepted: 18 May 2015 / Published: 26 May 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [730 KB, uploaded 26 May 2015]

Abstract

This study was performed to evaluate the phenolic profile, antioxidant and diuretic effects of black cumin and lady-in-a-mist seeds. In the phenolic profile, differences between the two species are significant. Qualitative and quantitative analyses of the phenolic compounds were performed using a HPLC-UV/MS method. Hyperoside was the only identified flavonoid glycoside (1.08 ± 0.01 μg∙g−1 dw plant material), in the N. damascena extract. Regarding the flavonol profile, kaempferol was identified before the hydrolysis, only in the N. sativa extract (6.06 ± 0.02 μg∙g−1 dw plant material) and quercetin only in N. damascena seeds (14.35 ± 0.02 μg∙g−1 dw plant material). The antioxidant potential of the two species was tested through several electron transfer assays, which indicated, excepting for the FRAP assay, N. damascena as exhibiting a higher free radical scavenging activity. The diuretic activity of the two extracts was tested using a rat-experimental model on acute diuresis. Administration of the ethanolic extract of N. sativa (100 mg∙kg−1) resulted in a significant increase in urine volume, although less than found with the reference drug; in addition N. damascena extract did not present a diuretic effect. In reference to the elimination of Na+, K+ and uric acid, the black cumin extract exhibited a higher natriuretic than kaluretic effect and a similar uricosuric effect with control and N. damascena. For N. damascena, the Na+/K+ ratio was sub unitary, but not due to an increasing of the kaluretic effect, but mostly to a decrease of Na+ excretion. View Full-Text
Keywords: Nigella sativa L.; N. damascena L.; polyphenols; antioxidants; diuretic; seeds Nigella sativa L.; N. damascena L.; polyphenols; antioxidants; diuretic; seeds
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Toma, C.-C.; Olah, N.-K.; Vlase, L.; Mogoșan, C.; Mocan, A. Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds. Molecules 2015, 20, 9560-9574.

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