Ethanolic Extracts of Pluchea indica Induce Apoptosis and Antiproliferation Effects in Human Nasopharyngeal Carcinoma Cells
AbstractPluchea indica is used in traditional medicine for the treatment of lumbago, ulcer, tuberculosis and inflammation. The anti-cancer activities and the underlying molecular mechanisms of the ethanolic extracts of P. indica root (PIRE) were characterized in the present study. PIRE strongly inhibited the viability of the human nasopharyngeal carcinoma cells (NPC-TW 01 and NPC-TW 04) in a time- and dose-dependent manner. Migration of cancer cells was also suppressed by PIRE. In addition, PIRE significantly increased the occurrence of the cells in sub-G1 phase and the extent of DNA fragmentation in a dose-dependent manner, which indicates that PIRE significantly increased apoptosis in NPC cells. The apoptotic process triggered by PIRE involved up-regulation of pro-apoptotic Bax protein and down-regulation of anti-apoptotic Bcl-2 protein, consequently increasing the ratios of Bax/Bcl-2 protein levels. Moreover, the p53 protein was up-regulated by PIRE in a concentration-dependent manner. Therefore, PIRE could induce the apoptosis-signaling pathway in NPC cells by activation of p53 and by regulation of apoptosis-related proteins. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Kao, C.-L.; Cho, J.; Lee, Y.-Z.; Cheng, Y.-B.; Chien, C.-Y.; Hwang, C.-F.; Hong, Y.-R.; Tseng, C.-N.; Cho, C.-L. Ethanolic Extracts of Pluchea indica Induce Apoptosis and Antiproliferation Effects in Human Nasopharyngeal Carcinoma Cells. Molecules 2015, 20, 11508-11523.
Kao C-L, Cho J, Lee Y-Z, Cheng Y-B, Chien C-Y, Hwang C-F, Hong Y-R, Tseng C-N, Cho C-L. Ethanolic Extracts of Pluchea indica Induce Apoptosis and Antiproliferation Effects in Human Nasopharyngeal Carcinoma Cells. Molecules. 2015; 20(6):11508-11523.Chicago/Turabian Style
Kao, Chiu-Li; Cho, Joshua; Lee, Ya-Zhe; Cheng, Yuan-Bin; Chien, Chih-Yen; Hwang, Chung-Feng; Hong, Yi-Ren; Tseng, Chao-Neng; Cho, Chung-Lung. 2015. "Ethanolic Extracts of Pluchea indica Induce Apoptosis and Antiproliferation Effects in Human Nasopharyngeal Carcinoma Cells." Molecules 20, no. 6: 11508-11523.