Protein Tyrosine Phosphatase 1B Inhibitors from the Roots of Cudrania tricuspidata
AbstractA chemical investigation of the methanol extract from the roots of Cudrania tricuspidata resulted in the isolation of 16 compounds, including prenylated xanthones 1–9 and flavonoids 10–16. Their structures were identified by NMR spectroscopy and mass spectrometry and comparisons with published data. Compounds 1–9 and 13–16 significantly inhibited PTP1B activity in a dose dependent manner, with IC50 values ranging from 1.9–13.6 μM. Prenylated xanthones showed stronger PTP1B inhibitory effects than the flavonoids, suggesting that they may be promising targets for the future discovery of novel PTP1B inhibitors. Furthermore, kinetic analyses indicated that compounds 1 and 13 inhibited PTP1B in a noncompetitive manner; therefore, they may be potential lead compounds in the development of anti-obesity and -diabetic agents. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 1369 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Quang, T.H.; Ngan, N.T.T.; Yoon, C.-S.; Cho, K.-H.; Kang, D.G.; Lee, H.S.; Kim, Y.-C.; Oh, H. Protein Tyrosine Phosphatase 1B Inhibitors from the Roots of Cudrania tricuspidata. Molecules 2015, 20, 11173-11183.
Quang TH, Ngan NTT, Yoon C-S, Cho K-H, Kang DG, Lee HS, Kim Y-C, Oh H. Protein Tyrosine Phosphatase 1B Inhibitors from the Roots of Cudrania tricuspidata. Molecules. 2015; 20(6):11173-11183.Chicago/Turabian Style
Quang, Tran H.; Ngan, Nguyen T.T.; Yoon, Chi-Su; Cho, Kwang-Ho; Kang, Dae G.; Lee, Ho S.; Kim, Youn-Chul; Oh, Hyuncheol. 2015. "Protein Tyrosine Phosphatase 1B Inhibitors from the Roots of Cudrania tricuspidata." Molecules 20, no. 6: 11173-11183.