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Molecules 2015, 20(6), 10839-10847; doi:10.3390/molecules200610839

A Halogen-Containing Stilbene Derivative from the Leaves of Cajanus cajan that Induces Osteogenic Differentiation of Human Mesenchymal Stem Cells

1
Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
2
Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
3
Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 25 April 2015 / Revised: 5 June 2015 / Accepted: 9 June 2015 / Published: 11 June 2015
(This article belongs to the Section Natural Products)
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Abstract

A new natural halogen-containing stilbene derivative was isolated from the leaves of Cajanus cajan (L.) Millsp. and identified as 3-O-(3-chloro-2-hydroxyl-propanyl)-longistylin A by comprehensive spectroscopic and chemical analysis, and named cajanstilbene H (1). It is the first halogen-containing stilbene derivative found from plants. In human mesenchymal stem cells (hMSC) from bone marrow, 1 did not promote cell proliferation, but distinctly enhanced osteogenic differentiation of hMSC in time- and dose-dependent manners. In six human cancer cell lines, 1 showed a moderate inhibitory effect on cell proliferation, with IC50 values of 21.42–25.85 μmol·L−1. View Full-Text
Keywords: Cajanus cajan (L.) Millsp.; stilbene; halogen; cajanstilbene H; osteogenic diffrentiation; human mesenchymal stem cells Cajanus cajan (L.) Millsp.; stilbene; halogen; cajanstilbene H; osteogenic diffrentiation; human mesenchymal stem cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cai, J.-Z.; Tang, R.; Ye, G.-F.; Qiu, S.-X.; Zhang, N.-L.; Hu, Y.-J.; Shen, X.-L. A Halogen-Containing Stilbene Derivative from the Leaves of Cajanus cajan that Induces Osteogenic Differentiation of Human Mesenchymal Stem Cells. Molecules 2015, 20, 10839-10847.

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