Next Article in Journal
Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides
Previous Article in Journal
Synthesis and Biological Evaluation of Novel Water-Soluble Poly-(ethylene glycol)-10-hydroxycamptothecin Conjugates
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(5), 9405-9418; doi:10.3390/molecules20059405

Cellular Structural Changes in Candida albicans Caused by the Hydroalcoholic Extract from Sapindus saponaria L.

Departamento Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Av. Colombo 5790, bloco T20, Maringá 87020-900, Brazil
Departamento de Farmácia, Universidade Estadual de Maringá, Av. Colombo 5790, bloco K80, Maringá 87020-900, Brazil
Departamento de Biologia Celular, Universidade Federal do Paraná, Curitiba 85131-990, Brazil
Campus Palotina, Universidade Federal do Paraná, Palotina 85950-000, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 December 2014 / Accepted: 27 January 2015 / Published: 22 May 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2199 KB, uploaded 22 May 2015]   |  


Vulvovaginal candidiasis (VVC) is a disease caused by the abnormal growth of yeast-like fungi in the mucosa of the female genital tract. Candida albicans is the principal etiological agent involved in VVC, but reports have shown an increase in the prevalence of Candida non-C. albicans (CNCA) cases, which complicates VVC treatment because CNCA does not respond well to antifungal therapy. Our group has reported the in vitro antifungal activity of extracts from Sapindus saponaria L. The present study used scanning electron microscopy and transmission electron microscopy to further evaluate the antifungal activity of hydroalcoholic extract from S. saponaria (HE) against yeast obtained from VVC and structural changes induced by HE. We observed the antifungal activity of HE against 125 vaginal yeasts that belonged to four different species of the Candida genus and S. cerevisae. The results suggest that saponins that are present in HE act on the cell wall or membrane of yeast at the first moments after contact, causing damage to these structures and cell lysis. View Full-Text
Keywords: vulvovaginal candidiasis; Sapindus saponaria; antifungals; saponins vulvovaginal candidiasis; Sapindus saponaria; antifungals; saponins

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shinobu-Mesquita, C.S.; Bonfim-Mendonça, P.S.; Moreira, A.L.; Ferreira, I.C.P.; Donatti, L.; Fiorini, A.; Svidzinski, T.I.E. Cellular Structural Changes in Candida albicans Caused by the Hydroalcoholic Extract from Sapindus saponaria L.. Molecules 2015, 20, 9405-9418.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top