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Molecules 2015, 20(5), 9295-9308; doi:10.3390/molecules20059295

Comparisons of the Pharmacokinetic Profile of Four Bioactive Components after Oral Administration of Gan-Sui-Ban-Xia Decoction Plus-Minus Gansui and Gancao Drug Combination in Normal Rats

1
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
2
The No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China
3
Basic Medical College, Beijing University of Chinese Medicine, Beijing 100092, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 3 April 2015 / Accepted: 18 May 2015 / Published: 20 May 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2501 KB, uploaded 21 May 2015]   |  

Abstract

Gan-Sui-Ban-Xia Decoction (GSBXD) was first presented by Zhang Zhongjing in the book Synopsis of Golden Chamber during the Han Dynasty period. The formula was then used for the treatment of persistent fluid retention with floating pulse in Traditional Chinese Medicine (TCM), which in modern medicine is known as malignant ascites. Here, a rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for the determination of glycyrrhizinic acid, liquiritin, paeoniflorin, albiflorin after oral administration of GSBXD plus-minus Gansui and Gancao anti-drug combination to investigate the possible pharmacokinetic profile differences of different prescriptions with GSBXD in normal rats. The differences of pharmacokinetic parameters among groups were tested by the Student’s t-test with p < 0.05 as the level of significance. Significant differences were found between the Gansui and Gancao anti-drug combination and other herbs in GSBXD on pharmacokinetic profile of glycyrrhizinic acid, liquiritin, paeoniflorin and albiflorin. The obtained knowledge might contribute to the rationality of the clinic use of GSBXD and also reveal the compatibility conditions of the Gansui and Gancao anti-drug combination. View Full-Text
Keywords: Gan-Sui-Ban-Xia Decoction; Gansui and Gancao anti-drug combination; UPLC–TQ/MS; pharmacokinetics influence Gan-Sui-Ban-Xia Decoction; Gansui and Gancao anti-drug combination; UPLC–TQ/MS; pharmacokinetics influence
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhang, Y.; Qian, D.; Pan, Y.; Zhu, Z.; Huang, J.; Xi, J.; Guo, J.; Zhou, X.; Zhong, G.; Duan, J. Comparisons of the Pharmacokinetic Profile of Four Bioactive Components after Oral Administration of Gan-Sui-Ban-Xia Decoction Plus-Minus Gansui and Gancao Drug Combination in Normal Rats. Molecules 2015, 20, 9295-9308.

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