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Molecules 2015, 20(5), 8605-8633; doi:10.3390/molecules20058605

Mentha suaveolens Ehrh. (Lamiaceae) Essential Oil and Its Main Constituent Piperitenone Oxide: Biological Activities and Chemistry

Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Sapienza University, P.le Aldo Moro 5, 00185 Rome, Italy
R.R. dedicates this work to the memory of his friend Aldo Peparello, passed away prematurely. Without his support this study would not have been conceived.
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 12 April 2015 / Revised: 3 May 2015 / Accepted: 8 May 2015 / Published: 13 May 2015
(This article belongs to the Section Natural Products)
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Abstract

Since herbal medicines play an important role in the treatment of a wide range of diseases, there is a growing need for their quality control and standardization. Mentha suaveolens Ehrh. (MS) is an aromatic herb with fruit and a spearmint flavor, used in the Mediterranean areas as a traditional medicine. It has an extensive range of biological activities, including cytotoxic, antimicrobial, antioxidant, anti-inflammatory, hypotensive and insecticidal properties, among others. This study aims to review the scientific findings and research reported to date on MS that prove many of the remarkable various biological actions, effects and some uses of this species as a source of bioactive natural compounds. On the other hand, piperitenone oxide (PO), the major chemical constituent of the carvone pathway MS essential oil, has been reported to exhibit numerous bioactivities in cells and animals. Thus, this integrated overview also surveys and interprets the present knowledge of chemistry and analysis of this oxygenated monoterpene, as well as its beneficial bioactivities. Areas for future research are suggested. View Full-Text
Keywords: Mentha suaveolens Ehrh.; essential oil; extracts; piperitenone oxide; biological activity Mentha suaveolens Ehrh.; essential oil; extracts; piperitenone oxide; biological activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Božović, M.; Pirolli, A.; Ragno, R. Mentha suaveolens Ehrh. (Lamiaceae) Essential Oil and Its Main Constituent Piperitenone Oxide: Biological Activities and Chemistry. Molecules 2015, 20, 8605-8633.

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