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Molecules 2015, 20(5), 8144-8167; doi:10.3390/molecules20058144

Hitting the Sweet Spot: Glycans as Targets of Fungal Defense Effector Proteins

Institute of Microbiology, Department of Biology, ETH Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland
Academic Editor: Els van Damme
Received: 2 April 2015 / Revised: 29 April 2015 / Accepted: 30 April 2015 / Published: 6 May 2015
(This article belongs to the Special Issue Protein-Carbohydrate Interactions, and Beyond)
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Abstract

Organisms which rely solely on innate defense systems must combat a large number of antagonists with a comparatively low number of defense effector molecules. As one solution of this problem, these organisms have evolved effector molecules targeting epitopes that are conserved between different antagonists of a specific taxon or, if possible, even of different taxa. In order to restrict the activity of the defense effector molecules to physiologically relevant taxa, these target epitopes should, on the other hand, be taxon-specific and easily accessible. Glycans fulfill all these requirements and are therefore a preferred target of defense effector molecules, in particular defense proteins. Here, we review this defense strategy using the example of the defense system of multicellular (filamentous) fungi against microbial competitors and animal predators. View Full-Text
Keywords: antibiosis; resistance; fungi; nematodes; bacteria; lectin; defensin; toxin; glycolipid; glycoprotein antibiosis; resistance; fungi; nematodes; bacteria; lectin; defensin; toxin; glycolipid; glycoprotein
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Künzler, M. Hitting the Sweet Spot: Glycans as Targets of Fungal Defense Effector Proteins. Molecules 2015, 20, 8144-8167.

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