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Molecules 2015, 20(5), 7807-7819; doi:10.3390/molecules20057807

Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties

1
Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia
2
Center of Research Excellence in Nanotechnology, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia
3
Physics Department, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia
4
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 3 March 2015 / Revised: 22 April 2015 / Accepted: 24 April 2015 / Published: 29 April 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [784 KB, uploaded 29 April 2015]   |  

Abstract

Two new DTPA-bis(amide) based ligands conjugated with the arylpiperazinyl moiety were synthesized and subsequently transformed into their corresponding Gd(III) complexes 1 and 2 of the type [Gd(L)H2O]·nH2O. The relaxivity (R1) of these complexes was measured, which turned out to be comparable with that of Omniscan®, a commercially available MRI contrast agent. The cytotoxicity studies of these complexes indicated that they are non-toxic, which reveals their potential and physiological suitability as MRI contrast agents. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods, including elemental analysis, 1H-NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry. View Full-Text
Keywords: DTPA-bis(amide); arylpiperazine; Gd(III)-complexes; MRI contrast agents; relaxivity; magneto-pharmaceuticals DTPA-bis(amide); arylpiperazine; Gd(III)-complexes; MRI contrast agents; relaxivity; magneto-pharmaceuticals
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ba-Salem, A.O.; Ullah, N.; Shaikh, M.N.; Faiz, M.; Ul-Haq, Z. Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties. Molecules 2015, 20, 7807-7819.

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