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Molecules 2015, 20(4), 7245-7262; doi:10.3390/molecules20047245

Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis

1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain
2
Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo Leon, PO Box 2316, Sucursal Tecnológico, Monterrey, NL 64841, Mexico
3
Servicio de Gastroenterología y Departamento de Patología Clínica, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo Leon, Av. Madero y Gonzalitos S/N, Mitras Centro, Monterrey, NL 64220, Mexico
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 2 February 2015 / Revised: 30 March 2015 / Accepted: 13 April 2015 / Published: 21 April 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [805 KB, uploaded 21 April 2015]   |  

Abstract

Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Some compounds showed antimycobacterial selectivity indices higher than leubethanol. View Full-Text
Keywords: serrulatane derivatives; leubethanol; semi-synthesis; in vitro antimycobacterial activity; cytotoxicity assay serrulatane derivatives; leubethanol; semi-synthesis; in vitro antimycobacterial activity; cytotoxicity assay
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Escarcena, R.; Perez-Meseguer, J.; del Olmo, E.; Alanis-Garza, B.; Garza-González, E.; Salazar-Aranda, R.; Waksman de Torres, N. Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis. Molecules 2015, 20, 7245-7262.

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