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Molecules 2015, 20(4), 6844-6855; doi:10.3390/molecules20046844

Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla

1
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Department of Laboratory Medicine, Paochien Care Cooperation Paochien Hospital, Pingtung 900, Taiwan
3
Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt
4
Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
5
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
6
School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
7
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
8
Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
9
Research Center for Natural Product and New Drug, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 13 March 2015 / Revised: 12 April 2015 / Accepted: 13 April 2015 / Published: 16 April 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2768 KB, uploaded 16 April 2015]   |  

Abstract

One new benzofuran, (2R)-(2',4'-dihydroxybenzyl)-6,7-methylenedioxy-2,3-dihydrobenzofuran (1), one new phenylisocoumarin, 3-(2'-hydroxyphenyl)-6,8-dihydroxy-7-methoxy-isocoumarin (2), and one new benzofuroisocoumarin, platyphyllarin C (3), were isolated from the ethanolic extract of Liriope platyphylla aerial parts, along with seventeen known compounds. The structures of the isolates were established by spectroscopic analysis and comparison with the literature data. The results indicated that structures 1–3 are uncommon in Nature. Benzofuroisocoumarin 4, flavonoids 9, 10, and 1315, and homoisoflavonoids 19 and 20 exhibited significant binding activity to estrogen-receptor α and/or β as demonstrated by the SEAP reporter assay system in an MCF-7 cell-line. View Full-Text
Keywords: Liliaceae; Liriope platyphylla; benzofuroisocoumarin; homoisoflavonoid; estrogenic activity; estrogen-receptor agonist Liliaceae; Liriope platyphylla; benzofuroisocoumarin; homoisoflavonoid; estrogenic activity; estrogen-receptor agonist
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tsai, Y.-C.; Hsu, C.-C.; El-Shazly, M.; Chiang, S.-Y.; Wu, C.-C.; Wu, C.-C.; Lai, W.-C.; Yen, M.-H.; Wu, Y.-C.; Chang, F.-R. Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla. Molecules 2015, 20, 6844-6855.

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