Next Article in Journal
Methanolic Extracts from Brown Seaweeds Dictyota cilliolata and Dictyota menstrualis Induce Apoptosis in Human Cervical Adenocarcinoma HeLa Cells
Next Article in Special Issue
Phytochemical Compositions and Biological Activities of Essential Oil from Xanthium strumarium L.
Previous Article in Journal
Quercitrin, an Inhibitor of Sortase A, Interferes with the Adhesion of Staphylococcal aureus
Previous Article in Special Issue
Thapsigargin—From Thapsia L. to Mipsagargin
Article Menu

Export Article

Open AccessReview
Molecules 2015, 20(4), 6544-6572; doi:10.3390/molecules20046544

Longevity Extension by Phytochemicals

Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 2 March 2015 / Revised: 7 April 2015 / Accepted: 8 April 2015 / Published: 13 April 2015
View Full-Text   |   Download PDF [741 KB, uploaded 13 April 2015]   |  


Phytochemicals are structurally diverse secondary metabolites synthesized by plants and also by non-pathogenic endophytic microorganisms living within plants. Phytochemicals help plants to survive environmental stresses, protect plants from microbial infections and environmental pollutants, provide them with a defense from herbivorous organisms and attract natural predators of such organisms, as well as lure pollinators and other symbiotes of these plants. In addition, many phytochemicals can extend longevity in heterotrophic organisms across phyla via evolutionarily conserved mechanisms. In this review, we discuss such mechanisms. We outline how structurally diverse phytochemicals modulate a complex network of signaling pathways that orchestrate a distinct set of longevity-defining cellular processes. This review also reflects on how the release of phytochemicals by plants into a natural ecosystem may create selective forces that drive the evolution of longevity regulation mechanisms in heterotrophic organisms inhabiting this ecosystem. We outline the most important unanswered questions and directions for future research in this vibrant and rapidly evolving field. View Full-Text
Keywords: phytochemicals; interspecies chemical signals; aging; longevity regulation mechanisms; evolution; ecosystems; hormesis; signaling pathways; stress response; metabolism phytochemicals; interspecies chemical signals; aging; longevity regulation mechanisms; evolution; ecosystems; hormesis; signaling pathways; stress response; metabolism

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Leonov, A.; Arlia-Ciommo, A.; Piano, A.; Svistkova, V.; Lutchman, V.; Medkour, Y.; Titorenko, V.I. Longevity Extension by Phytochemicals. Molecules 2015, 20, 6544-6572.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top