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Molecules 2015, 20(4), 6022-6032; doi:10.3390/molecules20046022

Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus

1
School of Marine Science, Ningbo University, Ningbo 315211, China
2
Department of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 10 March 2015 / Revised: 31 March 2015 / Accepted: 1 April 2015 / Published: 7 April 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1781 KB, uploaded 7 April 2015]   |  

Abstract

Cinnamaldehyde (CA) is marginally soluble in water, making it challenging to evenly disperse it in foods, and resulting in lowered anti-A. flavus efficacy. In the present study, nano-dispersed CA (nano-CA) was prepared to increase its aqueous solubility. Free and nano-dispersed CA were compared in terms of their inhibitory activity against fungal growth and aflatoxin production of A. flavus both in Sabouraud Dextrose (SD) culture and in peanut butter. Our results indicated that free CA inhibited the mycelia growth and aflatoxin production of A. flavus with a minimal inhibitory concentration (MIC) value of 1.0 mM, but promoted the aflatoxin production at some concentrations lower than the MIC. Nano-CA had a lower MIC value of 0.8 mM against A. flavus, and also showed improved activity against aflatoxin production without the promotion at lower dose. The solidity of peanut butter had an adverse impact on the antifungal activity of free CA, whereas nano-dispersed CA showed more than 2-fold improved activity against the growth of A. flavus. Free CA still promoted AFB1 production at the concentration of 0.25 mM, whereas nano-CA showed more efficient inhibition of AFB1 production in the butter. View Full-Text
Keywords: cinnamaldehyde; nano-dispersion; aflatoxin; inhibition; peanut butter cinnamaldehyde; nano-dispersion; aflatoxin; inhibition; peanut butter
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, H.; Shen, Q.; Zhou, W.; Mo, H.; Pan, D.; Hu, L. Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus. Molecules 2015, 20, 6022-6032.

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