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Molecules 2015, 20(4), 6002-6021; doi:10.3390/molecules20046002

Organic-Inorganic Hybrid Nanoparticles for Bacterial Inhibition: Synthesis and Characterization of Doped and Undoped ONPs with Ag/Au NPs

1
Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Coyoacán, 04510 México D.F., Mexico
2
Centre for Nanoscience & Nanotechnology, Panjab University, Chandigarh, Panjab 160014, India
3
Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar, Panjab 140001, India
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 21 January 2015 / Revised: 9 March 2015 / Accepted: 17 March 2015 / Published: 7 April 2015
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [12130 KB, uploaded 7 April 2015]   |  

Abstract

Organic nanoparticles (ONPs) of lipoic acid and its doped derivatives ONPs/Ag and ONPs/Au were prepared and characterized by UV-Visible, EDS, and TEM analysis. The antibacterial properties of the ONPs ONPs/Ag and ONPs/Au were tested against bacterial strains (Staphylococcus aureus, Bacillus cereus, Escherichia coli and Salmonella typhi). Minimal Inhibitory Concentration (MIC) and bacterial growth inhibition tests show that ONPs/Ag are more effective in limiting bacterial growth than other NPs, particularly, for Gram positive than for Gram-negative ones. The order of bacterial cell growth inhibition was ONPs/Ag > ONPs > ONPs/Au. The morphology of the cell membrane for the treated bacteria was analyzed by SEM. The nature of bond formation of LA with Ag or Au was analyzed by molecular orbital and density of state (DOS) using DFT. View Full-Text
Keywords: antibacterial studies; organic nanoparticles; lipoic acid; Staphylococcus aureus; Bacillus cereus; Escherichia coli; Salmonella typhi antibacterial studies; organic nanoparticles; lipoic acid; Staphylococcus aureus; Bacillus cereus; Escherichia coli; Salmonella typhi
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Aguilar, C.A.H.; Jiménez, A.B.P.; Silva, A.R.; Kaur, N.; Thangarasu, P.; Ramos, J.M.V.; Singh, N. Organic-Inorganic Hybrid Nanoparticles for Bacterial Inhibition: Synthesis and Characterization of Doped and Undoped ONPs with Ag/Au NPs. Molecules 2015, 20, 6002-6021.

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