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Molecules 2015, 20(3), 4681-4694; doi:10.3390/molecules20034681

Simultaneous Determination of Ferulic Acid and Phthalides of Angelica Sinensis Based on UPLC-Q-TOF/MS

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 4 January 2015 / Revised: 17 February 2015 / Accepted: 25 February 2015 / Published: 13 March 2015
(This article belongs to the Section Molecular Diversity)
View Full-Text   |   Download PDF [2135 KB, uploaded 13 March 2015]   |  

Abstract

The radix of Angelica sinensis (AS) is one of the most commonly used as a herbal medicine. To investigate the geoherbalism and quality evaluation of AS, an ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q-TOF/MS) method was established to analyze and identify ferulic acid and phthalides in AS. The results showed that among samples collected in four regions, the relative contents of ferulic acid and phthalides were highest in samples collected in Gansu, and the samples from the four different regions were apparently classified into four groups. Meanwhile, the relative content in non-fumigated root was higher than after sulfur-fumigation and the sulfur-fumigated and non-fumigated samples were obviously divided into two groups by PCA. The paper establishes a systematic and objective evaluation system to provide a scientific basis for evaluating the quality of AS. View Full-Text
Keywords: ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry; Angelica sinensis; geoherbalism; fingerprint ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry; Angelica sinensis; geoherbalism; fingerprint
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wei, W.-L.; Huang, L.-F. Simultaneous Determination of Ferulic Acid and Phthalides of Angelica Sinensis Based on UPLC-Q-TOF/MS. Molecules 2015, 20, 4681-4694.

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