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Molecules 2015, 20(3), 4548-4564; doi:10.3390/molecules20034548

Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence

1
School of Pharmacy, University of Otago, Dunedin 9056, New Zealand
2
Department of Pharmacy, University of Copenhagen, Copenhagen 2100, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 21 January 2015 / Revised: 3 March 2015 / Accepted: 3 March 2015 / Published: 12 March 2015
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Abstract

Antioxidants protect against damage from free radicals and are believed to slow the ageing process. Previously, we have reported the high antioxidant activity of 70% methanolic Sonchus oleraceus L. (Asteraceae) leaf extracts. We hypothesize that S. oleraceus extracts protect cells against H2O2-induced senescence by mediating oxidative stress. Premature senescence of young WI-38 cells was induced by application of H2O2. Cells were treated with S. oleraceus extracts before or after H2O2 stress. The senescence- associated β-galactosidase (SA-β-gal) activity was used to indicate cell senescence. S. oleraceus extracts showed higher cellular antioxidant activity than chlorogenic acid in WI-38 cells. S. oleraceus extracts suppressed H2O2 stress-induced premature senescence in a concentration-dependent manner. At 5 and 20 mg/mL, S. oleraceus extracts showed better or equivalent effects of reducing stress-induced premature senescence than the corresponding ascorbic acid treatments. These findings indicate the potential of S. oleraceus extracts to be formulated as an anti-ageing agent. View Full-Text
Keywords: Sonchus oleraceus; antioxidants; leaf extracts; caffeic acid derivatives; CAA; senescence; anti-ageing Sonchus oleraceus; antioxidants; leaf extracts; caffeic acid derivatives; CAA; senescence; anti-ageing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ou, Z.-Q.; Rades, T.; McDowell, A. Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence. Molecules 2015, 20, 4548-4564.

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