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Molecules 2015, 20(3), 3972-3985; doi:10.3390/molecules20033972

The Synthetic Antimicrobial Peptide Pexiganan and Its Nanoparticles (PNPs) Exhibit the Anti-Helicobacter pylori Activity in Vitro and in Vivo

1
The Department of Pharmacy, Food and Drug School, Anhui Science and Technology University, Fengyang 233100, China
2
The School of Life Science, University of Science and Technology of China, Hefei 230032, China
3
The Ministry of Agriculture Key Laboratory of Microbial Organic Fertilizer, Bengbu 233030, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 3 January 2015 / Revised: 25 February 2015 / Accepted: 26 February 2015 / Published: 2 March 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [726 KB, uploaded 2 March 2015]   |  

Abstract

The aim of this study was to probe the potential anti-H. pylori activity of the synthetic antimicrobial peptide pexiganan, which is an analog of the peptide magainin, and its nanoparticles (PNPs) that were prepared in our laboratory. To compare their antibacterial effects in vitro and in vivo, studies of H. pylori growth inhibition, kinetics and resistance assays were undertaken. The gastric mucoadhesive efficiency and H. pylori clearance efficiency of pexiganan and PNPs were evaluated in rats and mice infected with H. pylori. The eradication of H. pylori was determined using urease tests and a microbial culture method. We observed that PNPs adhered to gastric mucosa more effectively owing to a prolonged stay in the stomach, which resulted in a more effective H. pylori clearance. In addition, PNPs had greater anti-H. pylori effect than pexiganan in infected mice. The amount of pexiganan required to eradicate H. pylori was significantly less using PNPs than the corresponding pexiganan suspension. The results confirmed that PNPs improved peptide stability in the stomach and more effectively eradicated H. pylori from mice stomachs than pexiganan. View Full-Text
Keywords: antimicrobial peptide; pexiganan; nanoparticles; Helicobacter pylori antimicrobial peptide; pexiganan; nanoparticles; Helicobacter pylori
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhang, X.-L.; Jiang, A.-M.; Ma, Z.-Y.; Li, X.-B.; Xiong, Y.-Y.; Dou, J.-F.; Wang, J.-F. The Synthetic Antimicrobial Peptide Pexiganan and Its Nanoparticles (PNPs) Exhibit the Anti-Helicobacter pylori Activity in Vitro and in Vivo. Molecules 2015, 20, 3972-3985.

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