Anti-Tumor Activity of a Polysaccharide from Blueberry
AbstractBlueberries (Vaccinium spp.) are rich in bioactive compounds. However, the biological activity of polysaccharides from blueberry has not been reported so far. This study evaluated the anti-tumor and immunological activities of a polysaccharide (BBP3-1) from blueberry in S180-bearing mice. The experimental results indicated that BBP3-1 (100 mg·kg−1·d−1) inhibited the tumor growth rate by 73.4%. Moreover, this group, compared with the model control, had shown an effect of increasing both the spleen and thymus indices (p < 0.05), increasing phagocytosis by macrophages (p < 0.05), boosting the proliferation and transformation of lymphocytes (p < 0.01), promoting the secretion of TNF-α, IFN-γ, and IL-2 (p < 0.05) and improving NK cell activity (p < 0.01). From this study, we could easily conclude that BBP3-1 has the ability to inhibit tumor progression and could act as a good immunomodulator. View Full-Text
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Sun, X.; Liu, N.; Wu, Z.; Feng, Y.; Meng, X. Anti-Tumor Activity of a Polysaccharide from Blueberry. Molecules 2015, 20, 3841-3853.
Sun X, Liu N, Wu Z, Feng Y, Meng X. Anti-Tumor Activity of a Polysaccharide from Blueberry. Molecules. 2015; 20(3):3841-3853.Chicago/Turabian Style
Sun, Xiyun; Liu, Ning; Wu, Zhaoxia; Feng, Ying; Meng, Xianjun. 2015. "Anti-Tumor Activity of a Polysaccharide from Blueberry." Molecules 20, no. 3: 3841-3853.