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Molecules 2015, 20(3), 3854-3867; doi:10.3390/molecules20033854

Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor

1
Marine College, Shandong University at Weihai, No. 180, Wenhua West Road, Weihai 264209, China
2
State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 21 January 2015 / Revised: 15 February 2015 / Accepted: 24 February 2015 / Published: 2 March 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [852 KB, uploaded 2 March 2015]   |  

Abstract

In order to identify novel chlorantraniliprole derivatives as potential insecticides or fungicides, 25 analogues of chlorantraniliprole were synthesized. The insecticidal activities against oriental armyworm and the antifungal activities against five typical fungi of these derivatives were tested. Compounds 2u, 2x and 2y exhibited good activities against oriental armyworm, especially compounds 2u and 2x which showed higher larvicidal activities than indoxacarb. Moreover, all of the tested compounds exhibited activities against five typical fungi. The Ki values of all synthesized compounds were calculated using AutoDock4. The relationship between the Ki values and the results of insecticidal activities against oriental armyworm further indicated that the membrane-spanning domain protein of the ryanodine receptor might contain chlorantraniliprole binding sites. View Full-Text
Keywords: anthranilic diamides; chlorantraniliprole; ryanodine receptor; insecticidal activities; antifungal activities; molecular docking anthranilic diamides; chlorantraniliprole; ryanodine receptor; insecticidal activities; antifungal activities; molecular docking
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chen, Q.; Xiong, L.; Luo, M.; Wang, J.; Hu, C.; Zhang, X.; Yu, S.; Li, Y.; Sun, D. Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor. Molecules 2015, 20, 3854-3867.

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