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Open AccessCommunication
Molecules 2015, 20(2), 2850-2856; doi:10.3390/molecules20022850

New Cytotoxic Sesquiterpenoids from Siegesbeckia glabrescens

1,†
,
1,†
,
1
,
2,* and 1,*
1
Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea
2
Department of Natural Medicine Resources, Semyung University, Chungbuk 390-711, Korea
These authors are equally contributed to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 6 January 2015 / Accepted: 2 February 2015 / Published: 10 February 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [679 KB, uploaded 10 February 2015]   |  

Abstract

Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 14 showed differential cytotoxic effects on the target cancer cells with IC50 values in the range of 0.9–33.3 μM. View Full-Text
Keywords: Siegesbeckia glabrescens; compositae; sesquiterpenoids; cytotoxicity Siegesbeckia glabrescens; compositae; sesquiterpenoids; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wu, Q.; Li, H.; Lee, S.Y.; Lee, H.J.; Ryu, J.-H. New Cytotoxic Sesquiterpenoids from Siegesbeckia glabrescens. Molecules 2015, 20, 2850-2856.

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