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Molecules 2015, 20(2), 2591-2610; doi:10.3390/molecules20022591

Synthesis of Novel Triazoles, Tetrazine, Thiadiazoles and Their Biological Activities

1
Department of Chemistry, Faculty of Science, King Faisal University, Hofuf 31982, Saudi Arabia
2
Department of Chemistry, Faculty of Science, University of Beni Suef, Beni Suef 62511, Egypt
3
Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
*
Author to whom correspondence should be addressed.
Academic Editor: Roman Dembinski
Received: 1 December 2014 / Revised: 18 December 2014 / Accepted: 23 January 2015 / Published: 2 February 2015
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [1257 KB, uploaded 2 February 2015]   |  

Abstract

An expedient synthesis of novel triazoles, tetrazine and thiadiazoles, using conveniently accessible and commercially available starting materials has been achieved. The synthesized compounds were characterized by spectroscopic and elemental analyses, and screened for their antibacterial activities against four different strains, namely E. coli, P. aeruginosa, S. aureus and B. megaterium. In particular, the compounds 5, 24 and 26h exhibited excellent antibacterial activities compared to the reference antibiotic. To get further insight about their behavior, these compounds were tested for their antioxidant activities via SOD-like activity, DPPH free radical scavenging activity, ABST and NO, which showed promising results. Furthermore, these compounds effectively promoted the cleavage of genomic DNA as well, in the absence of any external additives. View Full-Text
Keywords: triazoles; tetrazine; thiadiazoles; antibacterial; antioxidant; DNA triazoles; tetrazine; thiadiazoles; antibacterial; antioxidant; DNA
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Al-Omair, M.A.; Sayed, A.R.; Youssef, M.M. Synthesis of Novel Triazoles, Tetrazine, Thiadiazoles and Their Biological Activities. Molecules 2015, 20, 2591-2610.

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