Next Article in Journal
A Sorghum MYB Transcription Factor Induces 3-Deoxyanthocyanidins and Enhances Resistance against Leaf Blights in Maize
Next Article in Special Issue
Emerging Structural Insights into Glycoprotein Quality Control Coupled with N-Glycan Processing in the Endoplasmic Reticulum
Previous Article in Journal
Preparation of a Titania/X-Zeolite/Porous Glass Composite Photocatalyst Using Hydrothermal and Drop Coating Processes
Previous Article in Special Issue
The Roles of Direct Recognition by Animal Lectins in Antiviral Immunity and Viral Pathogenesis
Article Menu

Export Article

Open AccessReview
Molecules 2015, 20(2), 2364-2387; doi:10.3390/molecules20022364

Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity

1
Nutrición y Bromatología, Facultad de Medicina and Centro de Investigación en Nutrición, Alimentación y Dietética (CINAD), Universidad de Valladolid, Valladolid 47005, Spain
2
Farmacia y Tecnología Farmacéutica, Facultad de Farmacia and Instituto Universitario de Farmacia Industrial (IUFI), Universidad Complutense de Madrid, Madrid 28040, Spain
3
Biología Celular, Histología y Farmacología, Facultad de Medicina and Instituto de Neurociencias de Castilla y León (INCYL), Universidad de Valladolid, Valladolid 47005, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Tzi Bun NG
Received: 17 November 2014 / Revised: 20 January 2015 / Accepted: 22 January 2015 / Published: 30 January 2015
(This article belongs to the Special Issue Lectins)
View Full-Text   |   Download PDF [2152 KB, uploaded 30 January 2015]   |  

Abstract

Sambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been somewhat restricted due to the presence of bioactive proteins or/and low molecular weight compounds whose ingestion could trigger deleterious effects. Over the last few years, the chemical and pharmacological characteristics of Sambucus species have been investigated. Among the proteins present in Sambucus species both type 1, and type 2 ribosome-inactivating proteins (RIPs), and hololectins have been reported. The biological role played by these proteins remains unknown, although they are conjectured to be involved in defending plants against insect predators and viruses. These proteins might have an important impact on the nutritional characteristics and food safety of elderberries. Type 2 RIPs are able to interact with gut cells of insects and mammals triggering a number of specific and mostly unknown cell signals in the gut mucosa that could significantly affect animal physiology. In this paper, we describe all known RIPs that have been isolated to date from Sambucus species, and comment on their antiviral and entomotoxic effects, as well as their potential uses. View Full-Text
Keywords: Sambucus ebulus L.; Sambucus nigra L.; ebulin; nigrin; immunotoxins; nigrin b model Sambucus ebulus L.; Sambucus nigra L.; ebulin; nigrin; immunotoxins; nigrin b model
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tejero, J.; Jiménez, P.; Quinto, E.J.; Cordoba-Diaz, D.; Garrosa, M.; Cordoba-Diaz, M.; Gayoso, M.J.; Girbés, T. Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity. Molecules 2015, 20, 2364-2387.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top