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Molecules 2015, 20(12), 21167-21177; doi:10.3390/molecules201219750

Improved Antioxidant Capacity of Optimization of a Self-Microemulsifying Drug Delivery System for Resveratrol

1
College of Life Sciences, Henan Normal University, Xinxiang 453007, China
2
College of Life Science and Biotechnology, Xinxiang Medical University, Xinxiang 453003, China
3
School of Life Science and Technology, Henan Institute of Science and Technology, Xinxiang 453003, China
*
Author to whom correspondence should be addressed.
Academic Editors: Thomas Rades, Holger Grohganz and Korbinian Löbmann
Received: 16 September 2015 / Revised: 13 November 2015 / Accepted: 17 November 2015 / Published: 27 November 2015
(This article belongs to the Collection Poorly Soluble Drugs)
View Full-Text   |   Download PDF [6183 KB, uploaded 27 November 2015]   |  

Abstract

The use of nano-encapsulated resveratrol (RSV) in self-micro-emulsified drug delivery systems (SMEDDS) formulations was investigated. Self-emulsifying grading tests were used to establish the optimal ratio of oil, surfactant, and co-surfactant. The optimized system was further investigated for the droplet size and zeta potential at the different medium pH values by a Malvern Zetasizer and transmission electron microscopy (TEM). The antioxidant capacity and cytotoxicity of the formulation were detected by DCFH-DA and a CCK-8 assays. The results showed that the nano-emulsion based on ethyl oleate, Tween-80, and PEG-400 (35:40:25, w/w/w) was the most stable formulation due to the small droplet size (approximately 50 nm) and high zeta potential in a neutral environment. Furthermore, this formulation also exhibited a greater antioxidant capacity with less toxicity than free RSV. Taken together, considering these results and the simple fabrication process, this formulation could be used to deliver nutritional food supplements in a stable, efficient, and safe manner. View Full-Text
Keywords: resveratrol; nano-encapsulation; self-emulsifying; oil-in-water; antioxidant; cytotoxicity resveratrol; nano-encapsulation; self-emulsifying; oil-in-water; antioxidant; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chen, Y.; Zhang, H.; Yang, J.; Sun, H. Improved Antioxidant Capacity of Optimization of a Self-Microemulsifying Drug Delivery System for Resveratrol. Molecules 2015, 20, 21167-21177.

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