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Molecules 2015, 20(12), 20998-21009; doi:10.3390/molecules201219744

Algae Undaria pinnatifida Protects Hypothalamic Neurons against Endoplasmic Reticulum Stress through Akt/mTOR Signaling

1
Institute of Medical Research, Dongguk University College of Medicine, Gyeongju 38066, Korea
2
Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Korea
3
Department of Biochemistry, Dongguk University College of Medicine, Gyeongju 38066, Korea
4
Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju 38066, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 5 October 2015 / Revised: 13 November 2015 / Accepted: 20 November 2015 / Published: 25 November 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2288 KB, uploaded 25 November 2015]   |  

Abstract

Increased endoplasmic reticulum (ER) stress is known to be one of the causes of hypothalamic neuronal damage, as well as a cause of metabolic disorders such as obesity and diabetes. Recent evidence has suggested that Undaria pinnatifida (UP), an edible brown algae, has antioxidant activity. However, the neuroprotective effect of UP has yet to be examined. In this study, to investigate the neuroprotective effect of UP on ER stress-induced neuronal damage in mouse hypothalamic neurons, mice immortal hypothalamic neurons (GT1-7) were incubated with extract of UP. ER stress was induced by treating with tunicamycin. Tunicamycin induced apoptotic cell death was compared with the vehicle treatment through excessive ER stress. However UP protected GT1-7 cells from cell death, occurring after treatment with tunicamycin by reducing ER stress. Treatment with UP resulted in reduced increment of ATF6 and CHOP, and recovered the decrease of phosphorylation of Akt/mTOR by tunicamycin and the increment of autophagy. These results show that UP protects GT1-7 cells from ER stress induced cell death through the Akt/mTOR pathway. The current study suggests that UP may have a beneficial effect on cerebral neuronal degeneration in metabolic diseases with elevated ER stress. View Full-Text
Keywords: Undaria pinnatifida; ER stress; apoptosis; autophagy; hypothalamus Undaria pinnatifida; ER stress; apoptosis; autophagy; hypothalamus
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MDPI and ACS Style

Kim, J.; Moon, I.S.; Goo, T.-W.; Moon, S.-S.; Seo, M. Algae Undaria pinnatifida Protects Hypothalamic Neurons against Endoplasmic Reticulum Stress through Akt/mTOR Signaling. Molecules 2015, 20, 20998-21009.

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