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Molecules 2015, 20(12), 20967-20978; doi:10.3390/molecules201219738

Pyranocoumarins from Root Extracts of Peucedanum praeruptorum Dunn with Multidrug Resistance Reversal and Anti-Inflammatory Activities

1,2,†
,
1,†
,
1
and
1,*
1
KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea
2
Korean Medicine Life Science, University of Science & Technology, Daejeon 34054, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 18 September 2015 / Revised: 10 November 2015 / Accepted: 17 November 2015 / Published: 25 November 2015
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [1766 KB, uploaded 25 November 2015]   |  

Abstract

In the search for novel herbal-based anticancer agents, we isolated a new angular-type pyranocoumarin, (+)-cis-(3′S,4′S)-3′-angeloyl-4′-tigloylkhellactone (1) along with 12 pyranocoumarins (213), two furanocoumarins (14, 15), and a polyacetylene (16) were isolated from the roots of Peucedanum praeruptorum using chromatographic separation methods. The structures of the compounds were determined using spectroscopic analysis with nuclear magnetic resonance (NMR) and high-resolution-electrospray ionization-mass spectrometry (HR-ESI-MS). The multidrug-resistance (MDR) reversal and anti-inflammatory effects of all the isolated compounds were evaluated in human sarcoma MES-SA/Dx5 and lipopolysaccharide (LPS)-induced RAW 264.7 cells. Among the 16 tested compounds, two (2 and 16) downregulated nitric oxide (NO) production and five (1, 7, 8, 11, and 13) inhibited the efflux of drugs by MDR protein, indicating the reversal of MDR. Therefore, these compounds may be potential candidates for the development of effective agents against MDR forms of cancer. View Full-Text
Keywords: Peucedanum praeruptorum; Umbelliferae; pyranocoumarin; multidrug resistance; anti-inflammation Peucedanum praeruptorum; Umbelliferae; pyranocoumarin; multidrug resistance; anti-inflammation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, J.; Lee, Y.J.; Kim, J.; Bang, O.-S. Pyranocoumarins from Root Extracts of Peucedanum praeruptorum Dunn with Multidrug Resistance Reversal and Anti-Inflammatory Activities. Molecules 2015, 20, 20967-20978.

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