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Molecules 2015, 20(11), 20312-20319; doi:10.3390/molecules201119699

Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells

1
Laboratory of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110001, China
2
Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China
3
Cancer Research Center, Key Laboratory of Brain and Spinal Cord Injury of Liaoning Province, and Laboratory Animal Center, the First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 25 September 2015 / Revised: 28 October 2015 / Accepted: 6 November 2015 / Published: 12 November 2015
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [2083 KB, uploaded 12 November 2015]   |  

Abstract

A series of butylphthalide derivatives (BPDs) 18 were isolated from the extract of the dried rhizome of Ligusticum chuanxiong Hort. (Umbelliferae). The cytotoxic activities of BPDs 18 were evaluated using a panel of human cancer cell lines. In addition, the SAR analysis and potential anti-invasion activities were investigated. The sp2 carbons at C-7 and C-7a appeared to be essential for the cytotoxic activities of BPDs. BPDs 5 and 6 remarkably inhibited the migration and invasion of cancer cells. The anti-invasion activity of dimer 6 was demonstrated to be significantly higher than monomer 5. View Full-Text
Keywords: Ligusticum chuanxiong; butylphthalides; cytotoxic activity; SAR; anti-invasion Ligusticum chuanxiong; butylphthalides; cytotoxic activity; SAR; anti-invasion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hu, Y.; Bi, X.; Zhao, P.; Zheng, H.; Huang, X. Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells. Molecules 2015, 20, 20312-20319.

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