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Molecules 2015, 20(10), 19252-19262; doi:10.3390/molecules201019252

Cytotoxicity of Triterpenes from Green Walnut Husks of Juglans mandshurica Maxim in HepG-2 Cancer Cells

1
College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
2
College of Adult Education, Heilongjiang University of Chinese Medicine, Harbin 150040, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Jean-Marc Sabatier
Received: 6 September 2015 / Revised: 15 October 2015 / Accepted: 19 October 2015 / Published: 22 October 2015
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [837 KB, uploaded 22 October 2015]   |  

Abstract

Among the classes of identified natural products, triterpenoids, one of the largest families, have been studied extensively for their diverse structures and variety of biological activities, including antitumor effects. In the present study, a phytochemical study of the green walnut husks of Juglans mandshurica Maxim led to the isolation of a new dammarane triterpene, 12β, 20(R), 24(R)-trihydroxydammar-25-en-3-one (6), together with sixteen known compounds, chiefly from chloroform and ethyl acetate extracts. According to their structural characteristics, these compounds were divided into dammarane-type, oleanane- and ursane-type. Dammarane-type triterpenoids were isolated for the first time from the Juglans genus. As part of our continuing search for biologically active compounds from this plant, all of these compounds were also evaluated for their cytotoxic activities against the growth of human cancer cells lines HepG-2 by the MTT assay. The results were shown that 20(S)-protopanaxadiol, 2α,3β,23-trihydroxyolean-12-en-28-oic acid and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibited better cytotoxicity in vitro with IC50 values of 10.32 ± 1.13, 16.13 ± 3.83, 15.97 ± 2.47 μM, respectively. Preliminary structure-activity relationships for these compounds were discussed. View Full-Text
Keywords: Juglans mandshurica Maxim; green walnut husks; triterpenoid aglycones; cytotoxic activity; structure-activity relationships Juglans mandshurica Maxim; green walnut husks; triterpenoid aglycones; cytotoxic activity; structure-activity relationships
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhou, Y.; Yang, B.; Liu, Z.; Jiang, Y.; Liu, Y.; Fu, L.; Wang, X.; Kuang, H. Cytotoxicity of Triterpenes from Green Walnut Husks of Juglans mandshurica Maxim in HepG-2 Cancer Cells. Molecules 2015, 20, 19252-19262.

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