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Molecules 2015, 20(10), 19172-19188; doi:10.3390/molecules201019172

Iridoids and Flavonoids of Four Siberian Gentians: Chemical Profile and Gastric Stimulatory Effect

1
Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, Sakh’yanovoy Str., 6, Ulan-Ude 670047, Russia
2
Department of Biochemistry and Biotechnology, North-Eastern Federal University, 58 Belinsky Str., Yakutsk 677027, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Christopher Lam
Received: 28 August 2015 / Revised: 15 October 2015 / Accepted: 16 October 2015 / Published: 21 October 2015
(This article belongs to the Collection Herbal Medicine Research)
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Abstract

Some Gentiana species have been used by the nomadic people of Siberia as bitter teas or appetizers to eliminate digestive disorders (dyspepsia, heartburn, nausea, etc.). We studied the most frequently used gentians: Gentiana algida, G. decumbens, G. macrophylla and G. triflora. The aim of the present study was to evaluate the phytochemical features and gastrostimulatnt activity of these four gentian herbs. Five iridoids, seven flavones and mangiferin were detected in gentian herbs after analysis by microcolumn-RP-HPLC-UV-ESI-MS. A componential phytochemical profile of the G. decumbens herb is presented for the first time, as well as information about distinct phytochemicals found in gentian herbs. HPLC quantification of the specific compounds of gentian herbs demonstrated the high content of iridoids (24.73–73.53 mg/g) and flavonoids (12.92–78.14 mg/g). The results of biological activity evaluation of four gentian decoctions demonstrated their good ability to stimulate acid-, enzyme- and mucin-forming functions of the stomach attributed to mostly by iridoids and flavonoids. In general, it can be claimed that the gentian decoctions can be used as effective and safe appetizers and are also a good source of biologically active agents. View Full-Text
Keywords: Gentiana algida; Gentiana decumbens; Gentiana macrophylla; Gentiana triflora; iridoids; flavonoids; HPLC; gastric secretion stimulation Gentiana algida; Gentiana decumbens; Gentiana macrophylla; Gentiana triflora; iridoids; flavonoids; HPLC; gastric secretion stimulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Olennikov, D.N.; Kashchenko, N.I.; Chirikova, N.K.; Tankhaeva, L.M. Iridoids and Flavonoids of Four Siberian Gentians: Chemical Profile and Gastric Stimulatory Effect. Molecules 2015, 20, 19172-19188.

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