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Molecules 2015, 20(10), 18620-18660; doi:10.3390/molecules201018620

A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models

1
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CP 5009, João Pessoa-PB, CEP 58051-970, Brazil
2
Departamento de Farmacologia, Universidade Federal do Paraná, CP 19031, Curitiba-PR, CEP 81540-970, Brazil
3
Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão-SE, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 August 2015 / Revised: 24 September 2015 / Accepted: 2 October 2015 / Published: 14 October 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [821 KB, uploaded 14 October 2015]   |  

Abstract

The clinical efficacy of standardized essential oils (such as Lavender officinalis), in treating anxiety disorders strongly suggests that these natural products are an important candidate source for new anxiolytic drugs. A systematic review of essential oils, their bioactive constituents, and anxiolytic-like activity is conducted. The essential oil with the best profile is Lavendula angustifolia, which has already been tested in controlled clinical trials with positive results. Citrus aurantium using different routes of administration also showed significant effects in several animal models, and was corroborated by different research groups. Other promising essential oils are Citrus sinensis and bergamot oil, which showed certain clinical anxiolytic actions; along with Achillea wilhemsii, Alpinia zerumbet, Citrus aurantium, and Spiranthera odoratissima, which, like Lavendula angustifolia, appear to exert anxiolytic-like effects without GABA/benzodiazepine activity, thus differing in their mechanisms of action from the benzodiazepines. The anxiolytic activity of 25 compounds commonly found in essential oils is also discussed. View Full-Text
Keywords: essential oil; terpene; natural products; anxiolytic; anxiety; tranquillizer; sedative; relaxant; elevated plus maze; lavender essential oil; terpene; natural products; anxiolytic; anxiety; tranquillizer; sedative; relaxant; elevated plus maze; lavender
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

de Sousa, D.P.; Hocayen, P.A.S.; Andrade, L.N.; Andreatini, R. A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models. Molecules 2015, 20, 18620-18660.

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