Next Article in Journal
Metabolic Profiling of Alpine and Ecuadorian Lichens
Next Article in Special Issue
Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception
Previous Article in Journal
Treatment Efficiency of Free and Nanoparticle-Loaded Mitoxantrone for Magnetic Drug Targeting in Multicellular Tumor Spheroids
Previous Article in Special Issue
Wheat Bran Phenolic Acids: Bioavailability and Stability in Whole Wheat-Based Foods
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(10), 18031-18046; doi:10.3390/molecules201018031

Plasma Pharmacokinetics of Polyphenols in a Traditional Japanese Medicine, Jumihaidokuto, Which Suppresses Propionibacterium acnes-Induced Dermatitis in Rats

1
Tsumura Research Laboratories, Kampo Scientific Strategies Division, Tsumura & Co., Ibaraki 300-1192, Japan
2
Kampo Formulations Development Center, Production Division, Tsumura & Co., Ibaraki 300-1192, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 26 August 2015 / Revised: 24 September 2015 / Accepted: 27 September 2015 / Published: 30 September 2015
View Full-Text   |   Download PDF [2480 KB, uploaded 30 September 2015]   |  

Abstract

Most orally administered polyphenols are metabolized, with very little absorbed as aglycones and/or unchanged forms. Metabolic and pharmacokinetic studies are therefore necessary to understand the pharmacological mechanisms of polyphenols. Jumihaidokuto (JHT), a traditional Japanese medicine, has been used for treatment of skin diseases including inflammatory acne. Because JHT contains various types of bioactive polyphenols, our aim was to clarify the metabolism and pharmacokinetics of the polyphenols in JHT and identify active metabolites contributing to its antidermatitis effects. Orally administered JHT inhibited the increase in ear thickness in rats induced by intradermal injection of Propionibacterium acnes. Quantification by LC-MS/MS indicated that JHT contains various types of flavonoids and is also rich in hydrolysable tannins, such as 1,2,3,4,6-penta-O-galloyl glucose. Pharmacokinetic and antioxidant analyses showed that some flavonoid conjugates, such as genistein 7-O-glucuronide and liquiritigenin 7-O-glucuronide, appeared in rat plasma and had an activity to inhibit hydrogen peroxide-dependent oxidation. Furthermore, 4-O-methylgallic acid, a metabolite of Gallic acid, appeared in rat plasma and inhibited the nitric oxide reaction. JHT has numerous polyphenols; it inhibited dermatitis probably via the antioxidant effect of its metabolites. Our study is beneficial for understanding in vivo actions of orally administered polyphenol drugs. View Full-Text
Keywords: jumihaidokuto; flavonoid; tannin; genistein; liquiritigenin; Gallic acid; glucuronides; pharmacokinetics; antioxidant; dermatitis jumihaidokuto; flavonoid; tannin; genistein; liquiritigenin; Gallic acid; glucuronides; pharmacokinetics; antioxidant; dermatitis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Matsumoto, T.; Matsubara, Y.; Mizuhara, Y.; Sekiguchi, K.; Koseki, J.; Tsuchiya, K.; Nishimura, H.; Watanabe, J.; Kaneko, A.; Maemura, K.; Hattori, T.; Kase, Y. Plasma Pharmacokinetics of Polyphenols in a Traditional Japanese Medicine, Jumihaidokuto, Which Suppresses Propionibacterium acnes-Induced Dermatitis in Rats. Molecules 2015, 20, 18031-18046.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top