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Molecules 2015, 20(1), 683-692; doi:10.3390/molecules20010683

Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis

1
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China
2
Tasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin 300410, China
3
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100050, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 17 November 2014 / Accepted: 31 December 2014 / Published: 6 January 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1334 KB, uploaded 6 January 2015]   |  

Abstract

Salvianolic acid Y (TSL 1), a new phenolic acid with the same planar structure as salvianolic acid B, was isolated from Salvia officinalis. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods, including 1D, 2D-NMR (1H-1H COSY, HMQC and HMBC) and circular dichroism (CD) experiments. The biosynthesis pathway of salvianolic acid B and salvianolic acid Y (TSL 1) was proposed based on structural analysis. The protection of PC12 cells from injury induced by H2O2 was assessed in vitro using a cell viability assay. Salvianolic acid Y (TSL 1) protected cells from injury by 54.2%, which was significantly higher than salvianolic acid B (35.2%). View Full-Text
Keywords: PC12 cells; Salvia officinalis; circular dichroism (CD) PC12 cells; Salvia officinalis; circular dichroism (CD)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gong, J.; Ju, A.; Zhou, D.; Li, D.; Zhou, W.; Geng, W.; Li, B.; Li, L.; Liu, Y.; He, Y.; Song, M.; Wang, Y.; Ye, Z.; Lin, R. Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis. Molecules 2015, 20, 683-692.

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