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Molecules 2015, 20(1), 1661-1675; doi:10.3390/molecules20011661

Deoxypodophyllotoxin Induces G2/M Cell Cycle Arrest and Apoptosis in SGC-7901 Cells and Inhibits Tumor Growth in Vivo

1
Jiangsu Center for Drug Screening, China Pharmaceutical University, Nanjing 210009, China
2
Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China
3
Medical and Chemical Institute, China Pharmaceutical University, Nanjing 210009, China
4
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 21 December 2014 / Revised: 4 January 2015 / Accepted: 13 January 2015 / Published: 20 January 2015
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Abstract

Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, was isolated from Anthriscus sylvestris, and a few studies have reported its anti-cancer effect. However, the in vivo antitumor efficacy of DPT is currently indeterminate. In this study, we investigated the anti-gastric cancer effects of DPT both in vitro and in vivo. Our data showed that DPT inhibited cancer cell proliferation and induced G2/M cell cycle arrest accompanied by an increase in apoptotic cell death in SGC-7901 cancer cells. In addition, DPT caused cyclin B1, Cdc2 and Cdc25C to accumulate, decreased the expression of Bcl-2 and activated caspase-3 and PARP, suggesting that caspase-mediated pathways were involved in DPT-induced apoptosis. Animal studies revealed that DPT significantly inhibited tumor growth and decreased microvessel density (MVD) in a xenograft model of gastric cancer. Taken together, our findings provide a framework for further exploration of DPT as a novel chemotherapeutic for human gastric cancer. View Full-Text
Keywords: deoxypodophyllotoxin; human gastric cancer; cell cycle arrest; apoptosis; anti-angiogenesis deoxypodophyllotoxin; human gastric cancer; cell cycle arrest; apoptosis; anti-angiogenesis
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MDPI and ACS Style

Wang, Y.-R.; Xu, Y.; Jiang, Z.-Z.; Guerram, M.; Wang, B.; Zhu, X.; Zhang, L.-Y. Deoxypodophyllotoxin Induces G2/M Cell Cycle Arrest and Apoptosis in SGC-7901 Cells and Inhibits Tumor Growth in Vivo. Molecules 2015, 20, 1661-1675.

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