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Molecules 2015, 20(1), 1519-1526; doi:10.3390/molecules20011519

Synthesis of Novel bis-1,5-Disubstituted-1H-Tetrazoles by an Efficient Catalyst-Free Ugi-Azide Repetitive Process

1
Departamento Química Área Ambiental, Universidad Tecnológica de Salamanca, Av. Universidad Tecnológica No. 200, Col. Ciudad Bajío, Salamanca C.P. 36750, Gto., Mexico
2
Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 26 November 2014 / Accepted: 25 December 2014 / Published: 16 January 2015
(This article belongs to the Section Organic Synthesis)
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Abstract

A series of five novel bis-1,5-disubstituted-1H-tetrazoles (bis-1,5-DS-1H-T) were quickly prepared by a catalyst-free Ugi-azide repetitive process from easily accessible starting materials in excellent yields, either at room temperature (88%–95%) or using mild MW-heating conditions (80%–91%). These molecules may have a wide range of applications, such as chelating agents, organocatalysts and luminescent materials, and mainly as bioactive compounds. View Full-Text
Keywords: bis-1,5-disubstituted-1H-tetrazoles; Ugi-azide repetitive reaction; MW-assisted synthesis; catalyst-free; chelating agents bis-1,5-disubstituted-1H-tetrazoles; Ugi-azide repetitive reaction; MW-assisted synthesis; catalyst-free; chelating agents
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cárdenas-Galindo, L.E.; Islas-Jácome, A.; Colmenero-Martínez, K.M.; Martínez-Richa, A.; Gámez-Montaño, R. Synthesis of Novel bis-1,5-Disubstituted-1H-Tetrazoles by an Efficient Catalyst-Free Ugi-Azide Repetitive Process. Molecules 2015, 20, 1519-1526.

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