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Molecules 2014, 19(9), 14919-14947; doi:10.3390/molecules190914919

Experimental Studies of the Molecular Pathways Regulated by Exercise and Resveratrol in Heart, Skeletal Muscle and the Vasculature

1
Department of Pharmacology & Therapeutics and the Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Research Theme of the Manitoba Institute of Child Health, University of Manitoba, 601 John Buhler Research Centre, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada
2
Department of Pediatrics and the Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, 458 Heritage Medical Research Centre, Edmonton, AB T6G 2S2, Canada
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 20 August 2014 / Revised: 10 September 2014 / Accepted: 10 September 2014 / Published: 18 September 2014
(This article belongs to the Special Issue Resveratrol)
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Abstract

Regular exercise contributes to healthy aging and the prevention of chronic disease. Recent research has focused on the development of molecules, such as resveratrol, that activate similar metabolic and stress response pathways as exercise training. In this review, we describe the effects of exercise training and resveratrol on some of the organs and tissues that act in concert to transport oxygen throughout the body. In particular, we focus on animal studies that investigate the molecular signaling pathways induced by these interventions. We also compare and contrast the effects of exercise and resveratrol in diseased states. View Full-Text
Keywords: resveratrol; exercise; mitochondria; reactive oxygen species; nitric oxide resveratrol; exercise; mitochondria; reactive oxygen species; nitric oxide
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Dolinsky, V.W.; Dyck, J.R.B. Experimental Studies of the Molecular Pathways Regulated by Exercise and Resveratrol in Heart, Skeletal Muscle and the Vasculature. Molecules 2014, 19, 14919-14947.

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