Next Article in Journal
Sorcin, a Calcium Binding Protein Involved in the Multidrug Resistance Mechanisms in Cancer Cells
Previous Article in Journal
Development of a Calcium Phosphate Nanocomposite for Fast Fluorogenic Detection of Bacteria
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(9), 13965-13975; doi:10.3390/molecules190913965

Total Aglycones from Marsdenia tenacissima Increases Antitumor Efficacy of Paclitaxel in Nude Mice

Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
*
Authors to whom correspondence should be addressed.
Received: 6 August 2014 / Revised: 23 August 2014 / Accepted: 1 September 2014 / Published: 5 September 2014
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1195 KB, uploaded 5 September 2014]   |  

Abstract

Marsdeniae tenacissimae Caulis (MTC) is a Chinese herbal medicine used mainly for treatment of cancer, whose pharmacologically active constituents responsible for its in vivo activity and clinical efficacy have not been clearly elucidated. In this study, total aglycones of MTC (ETA) showed the ability to sensitize KB-3-1, HeLa, HepG2 and K562 cells to paclitaxel treatment. More inspiringly, ETA markedly enhanced the antitumor activity of paclitaxel in nude mice bearing HeLa or KB-3-1 xenografts. Compared to treatment with paclitaxel alone, treatment with combination of paclitaxel and ETA achieved significant reduction in volume and weight of HeLa tumors (p < 0.05), and remarkable inhibition to the growth of KB-3-1 tumors (p < 10−6). ETA was characterized by the presence of a group of tenacigenin B ester derivatives, among which four reference compounds, 11α-O-tigloyl-12β-O-acetyltenacigenin B, 11α,12β-di-O-tigloyltenacigenin B, 11α-O-2-methylbutanoyl-12β-O-tigloyltenacigenin B, and 11α-O-(2-methylbutanoyl)-12β-O-benzoyltenacigenin B, accounted for 42.14% of the total peak area of 19 detectable components assayed by HPLC. Our study has identified ETA as a promising sensitizer for cancer chemotherapy. View Full-Text
Keywords: Marsdeniae tenacissimae Caulis; total aglycones; polyoxpregnane; paclitaxel; HeLa; KB-3-1; chemosensitizer Marsdeniae tenacissimae Caulis; total aglycones; polyoxpregnane; paclitaxel; HeLa; KB-3-1; chemosensitizer
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhu, R.-J.; Shen, X.-L.; Dai, L.-L.; Ai, X.-Y.; Tian, R.-H.; Tang, R.; Hu, Y.-J. Total Aglycones from Marsdenia tenacissima Increases Antitumor Efficacy of Paclitaxel in Nude Mice. Molecules 2014, 19, 13965-13975.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top