Next Article in Journal
Bifunctionalized Allenes. Part XV. Synthesis of 2,5-dihydro-1,2-oxaphospholes by Electrophilic Cyclization Reaction of Phosphorylated α-Hydroxyallenes
Previous Article in Journal
Calculating Distortions of Short DNA Duplexes with Base Pairing Between an Oxidatively Damaged Guanine and a Guanine
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(8), 11045-11055; doi:10.3390/molecules190811045

Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh

1
Department of Identification of Traditional Chinese Medicine, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macau, China
3
Department of Pharmacy, Changzheng Hospital, Shanghai 200003, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 18 June 2014 / Revised: 9 July 2014 / Accepted: 16 July 2014 / Published: 29 July 2014
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [828 KB, uploaded 30 July 2014]   |  

Abstract

Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O- [4ꞌ,6ꞌ-(S)-hexahydroxydiphenoyl]-β-D-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-D-glucose(3), pinocembrin-7-O-[3ꞌꞌ-O- galloyl- 4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-D-glucose (4), thonningianin A (5), and thonningianin B (6) were isolated from Penthourm chinense. All compounds were evaluated for their anti-proliferative activity in HSC-T6 cells, and 2 and 5 showed significant activity, with IC50 values of 12.7 and 19.2 μM, respectively. View Full-Text
Keywords: Penthorum chinense; polyphenols; anti-proliferative activity Penthorum chinense; polyphenols; anti-proliferative activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Huang, D.; Jiang, Y.; Chen, W.; Yao, F.; Sun, L. Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh. Molecules 2014, 19, 11045-11055.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top