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Molecules 2014, 19(8), 11045-11055; https://doi.org/10.3390/molecules190811045

Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh

1
Department of Identification of Traditional Chinese Medicine, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macau, China
3
Department of Pharmacy, Changzheng Hospital, Shanghai 200003, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 18 June 2014 / Revised: 9 July 2014 / Accepted: 16 July 2014 / Published: 29 July 2014
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O- [4ꞌ,6ꞌ-(S)-hexahydroxydiphenoyl]-β-D-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-D-glucose(3), pinocembrin-7-O-[3ꞌꞌ-O- galloyl- 4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-D-glucose (4), thonningianin A (5), and thonningianin B (6) were isolated from Penthourm chinense. All compounds were evaluated for their anti-proliferative activity in HSC-T6 cells, and 2 and 5 showed significant activity, with IC50 values of 12.7 and 19.2 μM, respectively. View Full-Text
Keywords: Penthorum chinense; polyphenols; anti-proliferative activity Penthorum chinense; polyphenols; anti-proliferative activity
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Huang, D.; Jiang, Y.; Chen, W.; Yao, F.; Sun, L. Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh. Molecules 2014, 19, 11045-11055.

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