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Molecules 2014, 19(7), 9986-9998; https://doi.org/10.3390/molecules19079986

Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study

1
Laboratory of Organic Chemistry, University of Mons-UMONS, 23 Place du Parc, B-7000 Mons, Belgium
2
SAIREM SAS, 12 porte du Grand Lyon, F-01702 Neyron, France
*
Author to whom correspondence should be addressed.
Received: 23 May 2014 / Revised: 19 June 2014 / Accepted: 26 June 2014 / Published: 9 July 2014
(This article belongs to the Special Issue ECSOC-17)
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Abstract

Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates have been prepared in a batch mode under conventional heating as well as under continuous flow conditions in the Miniflow 200SS, Sairem’s microwave-assisted batch and continuous flow equipment. Real-time monitoring of the reactions by Raman spectroscopy enabled to compare both heating modes and to determine (optimized) reaction times. View Full-Text
Keywords: 1,4-DHPs; flow chemistry; Hantzsch pyridines; microwave; Raman spectroscopy; real-time monitoring 1,4-DHPs; flow chemistry; Hantzsch pyridines; microwave; Raman spectroscopy; real-time monitoring
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Christiaens, S.; Vantyghem, X.; Radoiu, M.; Vanden Eynde, J.J. Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study. Molecules 2014, 19, 9986-9998.

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