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Molecules 2014, 19(7), 9101-9113; doi:10.3390/molecules19079101

Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H2O2-Injured PC12 Cells of Glycyrrhiza Glabra L. Leaf and Root Extracts

1
College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China
2
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China
*
Author to whom correspondence should be addressed.
Received: 15 May 2014 / Revised: 24 June 2014 / Accepted: 25 June 2014 / Published: 30 June 2014
(This article belongs to the Section Natural Products)
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Abstract

This study compared the total flavonoid content of Glycyrrhiza glabra L. leaf and root extracts. Results suggested that the total flavonoid content in the leaf extract was obviously higher than that in the root extract. Pinocembrin, the main compound in the leaf extract after purification by column chromatography, showed good antioxidant activity and nitrite scavenging capacity, but moderate inhibitory effect on mushroom tyrosinase. Liquiritin was the main compound in root extract and possessed strong inhibitory effect on mushroom tyrosinase. Both compounds exhibited significant protection effect on H2O2-injured PC12 cells at a low concentration. These results indicate that Glycyrrhiza glabra L. leaf is potential as an important raw material for functional food. View Full-Text
Keywords: Glycyrrhiza glabra L. leaf; nitrite scavenging capacity; tyrosinase inhibitory activity; PC12 cells; pinocembrin; liquiritin Glycyrrhiza glabra L. leaf; nitrite scavenging capacity; tyrosinase inhibitory activity; PC12 cells; pinocembrin; liquiritin
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Dong, Y.; Zhao, M.; Zhao, T.; Feng, M.; Chen, H.; Zhuang, M.; Lin, L. Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H2O2-Injured PC12 Cells of Glycyrrhiza Glabra L. Leaf and Root Extracts. Molecules 2014, 19, 9101-9113.

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