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Molecules 2014, 19(7), 9089-9100; doi:10.3390/molecules19079089

Cholesteryl-Modification of a Glucomannan from Bletilla striata and Its Hydrogel Properties

1
School of Life Sciences, Northeast Normal University, Changchun 130024, China
2
Pharmacy Department, Chinese People's Liberation Army 208 Hospital, Changchun 130062, China
*
Author to whom correspondence should be addressed.
Received: 25 May 2014 / Revised: 21 June 2014 / Accepted: 24 June 2014 / Published: 30 June 2014
(This article belongs to the Section Natural Products)
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Abstract

A glucomannan-type polysaccharide, named BSP, was obtained from the tubers of Bletilla striata by ultrasonic-assisted extraction, ethanol precipitation, deproteination and gel-permeation chromatography. HPLC analysis revealed that BSP contained mannose and glucose in the molar ratio of 3.5:1. Its molecular weight (Mw) was estimated to be 20 kDa. Methylation analysis, FT-IR and NMR analyses indicated that BSP consisted of (1→4)-linked β-D-glucopyranosyl residues and (1→4)-linked β-D-mannopyranosyl residues. Cholesteryl succinate was linked to BSP to make it more amphiphilic and the degree of substitution of cholesteryl succinate-BSP was 3.2%. The critical micelle concentration of modified BSP was 0.001 mg/mL, suggesting it could self-assemble into nanoparticles in aqueous solution. View Full-Text
Keywords: cholesteryl-modification; glucomannan; Bletilla striata; hydrogel property cholesteryl-modification; glucomannan; Bletilla striata; hydrogel property
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Zhang, M.; Sun, L.; Zhao, W.; Peng, X.; Liu, F.; Wang, Y.; Bi, Y.; Zhang, H.; Zhou, Y. Cholesteryl-Modification of a Glucomannan from Bletilla striata and Its Hydrogel Properties. Molecules 2014, 19, 9089-9100.

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