Next Article in Journal
Evidence for the Involvement of Spinal Cord-Inhibitory and Cytokines-Modulatory Mechanisms in the Anti-Hyperalgesic Effect of Hecogenin Acetate, a Steroidal Sapogenin-Acetylated, in Mice
Next Article in Special Issue
Regulatory Effects of Fisetin on Microglial Activation
Previous Article in Journal
Magnetic Pycnoporus sanguineus-Loaded Alginate Composite Beads for Removing Dye from Aqueous Solutions
Previous Article in Special Issue
Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(6), 8289-8302; doi:10.3390/molecules19068289

A PPARγ, NF-κB and AMPK-Dependent Mechanism May Be Involved in the Beneficial Effects of Curcumin in the Diabetic db/db Mice Liver

Departamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León, Universidad de Guanajuato. León, 37320, Mexico
*
Author to whom correspondence should be addressed.
Received: 11 April 2014 / Revised: 6 June 2014 / Accepted: 12 June 2014 / Published: 18 June 2014
(This article belongs to the Special Issue Natural Antioxidants and Ageing)
View Full-Text   |   Download PDF [997 KB, uploaded 18 June 2014]   |  

Abstract

Turmeric (Curcuma longa) is a rhizomatous herbaceous perennial plant of the ginger family which has been used to treat biliary disorders, anorexia, cough, rheumatism, cancer, sinusitis, hepatic disorders, hyperglycemia, obesity, and diabetes in both Ayurvedic and Traditional Chinese Medicine. Suggested mechanisms of action include the modulation of signal transduction cascades and effects on gene expression, however they remain to be elucidated. In this study, the expression of some proteins responsible for transcription factors, inflammation, and metabolic control were evaluated by western blot in 15-week-old db/db mice livers treated with curcumin 0.75% mixed in their diet for 8 weeks. In addition, nitrosative stress was evaluated. Curcumin increased the expression of AMPK and PPARγ, and diminished NF-κB protein in db/db mice. However, it did not modify the expression of PGC-1α or SIRT1. Nitrosative stress present in db/db mice livers was determined by a unique nitrotyrosylated protein band (75 kDa) and was not reverted with curcumin. In conclusion, curcumin regulates the expression of AMPK, PPARγ, and NF-κB; suggesting a beneficial effect for treatment of T2DM complications. In order to observe best beneficial effects it is desirable to administer curcumin in the earlier states of T2DM. View Full-Text
Keywords: antioxidants; Curcuma longa; diabetes; inflammation; obesity; polyphenols antioxidants; Curcuma longa; diabetes; inflammation; obesity; polyphenols
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Jiménez-Flores, L.M.; López-Briones, S.; Macías-Cervantes, M.H.; Ramírez-Emiliano, J.; Pérez-Vázquez, V. A PPARγ, NF-κB and AMPK-Dependent Mechanism May Be Involved in the Beneficial Effects of Curcumin in the Diabetic db/db Mice Liver. Molecules 2014, 19, 8289-8302.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top