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Molecules 2014, 19(6), 8140-8150; doi:10.3390/molecules19068140

Synthesis and Fungicidal Activity of Novel Chloro-Containing 1-Aryl-3-oxypyrazoles with an Oximino Ester or Oximino Amide Moiety

1
Department of Chemical and Pharmaceutical Engineering, Southeast University ChengXian College, Nanjing 210088, China
2
College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China
3
College of Science, Nanjing Tech University, Nanjing 211816, China
*
Authors to whom correspondence should be addressed.
Received: 25 April 2014 / Revised: 9 June 2014 / Accepted: 12 June 2014 / Published: 17 June 2014
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Abstract

Six novel chloro-containing 1-aryl-3-oxypyrazoles TMaTMf with an oximino ester or an oximino amide moiety were prepared by the reaction of 1-aryl-1H-pyrazol-3-ols with benzyl bromide. Their structures were characterized by 1H-NMR, 13C-NMR, IR, MS, and elemental analysis. A preliminary in vitro bioassay indicated that compounds TMa, TMe and TMf displayed excellent fungicidal activity against Rhizoctonia solani and could be used as potential lead compounds for further development of novel fungicides. View Full-Text
Keywords: synthesis; fungicidal activity; chloro-containing 1-aryl-3-oxypyrazoles; structure-activity relationships synthesis; fungicidal activity; chloro-containing 1-aryl-3-oxypyrazoles; structure-activity relationships
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Liu, Y.; Li, Y.; Chen, N.; Lv, K.; Zhou, C.; Xiong, X.; Li, F. Synthesis and Fungicidal Activity of Novel Chloro-Containing 1-Aryl-3-oxypyrazoles with an Oximino Ester or Oximino Amide Moiety. Molecules 2014, 19, 8140-8150.

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