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Molecules 2014, 19(5), 5863-5875; doi:10.3390/molecules19055863

Norditerpenoids from Flickingeria fimbriata and Their Inhibitory Activities on Nitric Oxide and Tumor Necrosis Factor-α Production in Mouse Macrophages

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, Guangdong, China
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Received: 10 March 2014 / Revised: 21 April 2014 / Accepted: 28 April 2014 / Published: 6 May 2014
(This article belongs to the Section Natural Products)
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Abstract

Bioassay-guided fractionation of the ethanolic extract of the leaves of Flickingeria flimbriata led to the isolation of two new degraded diterpenoids 1 and 2, a new ent-pimarane type diterpenoid 3, and four known steroids 47. The structures of 13 were elucidated by spectroscopic analysis, and their absolute configurations were determined by chemical methods, TDDFT quantum chemical calculations of ECD spectra, and CD exiton chirality method. Compounds 1 and 2, named flickinflimilins A and B, possess a rare 15,16-dinor-ent-pimarane skeleton. Compounds 17 were screened for the inhibitory activity against lipopolysaccharide (LPS)-induced NO and TNF-α production in RAW264.7 cells. Compounds 13 exhibited potent inhibitory activities, with IC50 values of less than 10 µM.
Keywords: norditerpenoid; TDDFT; exiton chirality method; NO; TNF-α norditerpenoid; TDDFT; exiton chirality method; NO; TNF-α
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MDPI and ACS Style

Chen, J.-L.; Zhong, W.-J.; Tang, G.-H.; Li, J.; Zhao, Z.-M.; Yang, D.-P.; Jiang, L. Norditerpenoids from Flickingeria fimbriata and Their Inhibitory Activities on Nitric Oxide and Tumor Necrosis Factor-α Production in Mouse Macrophages. Molecules 2014, 19, 5863-5875.

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