Next Article in Journal
Cobalt-Catalyzed Methoxycarbonylation of Substituted Dichlorobenzenes as an Example of a Facile Radical Anion Nucleophilic Substitution in Chloroarenes
Previous Article in Journal
Significance and Therapeutic Value of miRNAs in Embryonal Neural Tumors
Molecules 2014, 19(5), 5863-5875; doi:10.3390/molecules19055863
Article

Norditerpenoids from Flickingeria fimbriata and Their Inhibitory Activities on Nitric Oxide and Tumor Necrosis Factor-α Production in Mouse Macrophages

,
,
,
,
,
*  and *
Received: 10 March 2014 / Revised: 21 April 2014 / Accepted: 28 April 2014 / Published: 6 May 2014
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [452 KB, uploaded 18 June 2014]   |   Browse Figures

Abstract

Bioassay-guided fractionation of the ethanolic extract of the leaves of Flickingeria flimbriata led to the isolation of two new degraded diterpenoids 1 and 2, a new ent-pimarane type diterpenoid 3, and four known steroids 47. The structures of 13 were elucidated by spectroscopic analysis, and their absolute configurations were determined by chemical methods, TDDFT quantum chemical calculations of ECD spectra, and CD exiton chirality method. Compounds 1 and 2, named flickinflimilins A and B, possess a rare 15,16-dinor-ent-pimarane skeleton. Compounds 17 were screened for the inhibitory activity against lipopolysaccharide (LPS)-induced NO and TNF-α production in RAW264.7 cells. Compounds 13 exhibited potent inhibitory activities, with IC50 values of less than 10 µM.
Keywords: norditerpenoid; TDDFT; exiton chirality method; NO; TNF-α norditerpenoid; TDDFT; exiton chirality method; NO; TNF-α
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplement

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Chen, J.-L.; Zhong, W.-J.; Tang, G.-H.; Li, J.; Zhao, Z.-M.; Yang, D.-P.; Jiang, L. Norditerpenoids from Flickingeria fimbriata and Their Inhibitory Activities on Nitric Oxide and Tumor Necrosis Factor-α Production in Mouse Macrophages. Molecules 2014, 19, 5863-5875.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert